Bipolar Disorder Article Example | Topics and Well Written Essays - 250 words

Bipolar Disorder - Article ExampleThe basis of this composition is an association between the deregulation of HPA axis and BD diagnosis, present in all clinical cases of BD.A dys operation of the HPA axis may be caused by an alteration the rate limiting step of cortisol metabolism. A mitochondrial membrane translocator protein (TSPO) is a blusher regulator in this pathway as it limits the translocation of cholesterol into the power house (Colasanti, Owen, & Grozeva, et al., 2013). An amino acid replacement polymorphism (rs 6971) in the gene encoding for this transporter protein greatly affects the affinity of TSPO to cholesterol. This altered affinity in the defective protein in turn impairs the metabolism of steroids including those of HPA axis. This study provides evidence of association between a wholeness nucleotide polymorphism in the TSPO gene and the diagnosis of bipolar disorder in a big(p) scale case control study (Colasanti, Owen, & Grozeva, et al., 2013). However, the results of this study atomic number 18 suggestive as the findings did not meet genome wise significance though they were reproducible. This nominal association suggests the possible existence of other confounding factors in the etiopathogenesis of bipolar disorder. A limitation of this study is in the use of imputation in the analysis for the rs6971 SNP in the TSPO gene.In conclusion, a bipolar disorder is a mental illness characterized by mood swings. There are several environmental and genetic etiologies to this condition, which can progress to severe forms such as psychosis. A study by Colasanti, Owen, and Grozeva, et al., suggests a possible genetically altered HPA axis function as a actuating(prenominal) factor in BD. The genetic mutation in the mitochondrial translocator protein (TSPO) impairs the metabolism of neurosteroids, which in turn alters the HPA axis function (Colasanti, Owen, & Grozeva, et al., 2013). The deregulation in HPA axis has been reported in all BD cases suggesting a